HCID 86740010, compound → HCID 13456432, compound

HRID 1980301Notes

Reaction equation

HRID 1980301 reaction equation
C(O)(=O)/C=C\C(O)=O.[CH2:9]([O:11][C:12]([C@@H:14]([NH:23][C@@H:24]([CH3:35])[C:25]([O:27]CC1C=CC=CC=1)=[O:26])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[O:13])[CH3:10]>[Pd]>[CH2:9]([O:11][C:12]([C@@H:14]([NH:23][C@@H:24]([CH3:35])[C:25]([OH:27])=[O:26])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[O:13])[CH3:10]

Participants

3

Reactant 1

HCID 86740010HCID 86740010, compound

Product 1

HCID 13456432HCID 13456432, compoundYield 75.9%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

16.8 g of benzyl (2S)-2-[N-((1S)-1-ethoxycarbonyl-n-nonyl)amino]propionate maleate and 200 mg of palladium black are treated in the same manner as described in Preparation 6-(2). The residue is crystallized with a mixture of ether and n-hexane. 7.42 g of (2S)-2-[N-((1S)-1-ethoxycarbonyl-n-nonyl)amino]propionic acid are obtained as colorless crystals. Yield: 75.9%

Workup

  1. customas described in Preparation 6-(2)
  2. customThe residue is crystallized with a mixture of ether and n-hexane

Sources & evidence

ORD record
ord-222c1e4d85c04c658a284db1444e4401
Source dataset
uspto-grants-1985_04
Patent number
US04508727

Reaction notes

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