2-Chlorobenzoyl isocyanate → 1-(2-Chlorobenzoyl)-3-(5-(4-chlorophenyl)-2-pyridyl)urea

HRID 1980309Notes

Reaction equation

HRID 1980309 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11]([NH2:14])=[N:12][CH:13]=2)=[CH:4][CH:3]=1.[Cl:15][C:16]1[CH:26]=[CH:25][CH:24]=[CH:23][C:17]=1[C:18]([N:20]=[C:21]=[O:22])=[O:19]>>[Cl:15][C:16]1[CH:26]=[CH:25][CH:24]=[CH:23][C:17]=1[C:18]([NH:20][C:21]([NH:14][C:11]1[CH:10]=[CH:9][C:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)=[CH:13][N:12]=1)=[O:22])=[O:19]

Participants

3

Reactant 2

HCID 99423112-Chlorobenzoyl isocyanateHCID 132426445-(4-Chlorophenyl)pyridin-2-amine

Product 1

HCID 132426471-(2-Chlorobenzoyl)-3-(5-(4-chlorophenyl)-2-pyridyl)urea

Procedure

5-(4-Chlorophenyl)-2-pyridylamine (0.6 gram) and 2-chlorobenzoyl isocyanate (0.7 gram) were reacted according to the teaching of Example 7. The identity of the product was confirmed by NMR, yield 920 mg, m.p. 228°-231° C.

Sources & evidence

ORD record
ord-6944b280585d46ce8fd61e6666967561
Source dataset
uspto-grants-1985_04
Patent number
US04508722

Reaction notes

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