反应详情

A mixture of 6-methyl-5-phenyl-2-pyridone (12.0 grams) and phenylphosphorodiamidate (14.4 grams) in 300 ml diphenyl ether was heated for 19-20 hours at approximately 220°-225° [250]° C. After cooling, the reaction mixture was chromatographed over silica gel with ethyl acetate. A total of 0.8 gram, of desired product was collected and recrystallized from dichloromethane/petroleum ether, m.p. 110°-113° C.

1. temperaturewas heated for 19-20 hours at approximately 220°-225° [250]° C
2. temperatureAfter cooling
3. customthe reaction mixture was chromatographed over silica gel with ethyl acetate
4. customA total of 0.8 gram, of desired product was collected
5. customrecrystallized from dichloromethane/petroleum ether, m.p. 110°-113° C.