2,6-Dichlorobenzoyl isocyanate → 1-(2,6-Dichlorobenzoyl)-3-(4,6-dimethyl-5-phenyl-2-pyridyl)urea

HRID 1980322Notes

Reaction equation

HRID 1980322 reaction equation
[CH3:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[C:6]([CH3:14])[N:5]=[C:4]([NH2:15])[CH:3]=1.[Cl:16][C:17]1[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[C:18]=1[C:19]([N:21]=[C:22]=[O:23])=[O:20]>C(OCC)(=O)C>[Cl:16][C:17]1[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[C:18]=1[C:19]([NH:21][C:22]([NH:15][C:4]1[CH:3]=[C:2]([CH3:1])[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[C:6]([CH3:14])[N:5]=1)=[O:23])=[O:20]

Participants

4

Reactant 2

HCID 129127392,6-Dichlorobenzoyl isocyanateHCID 135028544,6-Dimethyl-5-phenyl-2-pyridylamine

Product 1

HCID 132426541-(2,6-Dichlorobenzoyl)-3-(4,6-dimethyl-5-phenyl-2-pyridyl)urea

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4,6-Dimethyl-5-phenyl-2-pyridylamine (500 mg) and 2,6-dichlorobenzoyl isocyanate (650 mg) were reacted in 25 ml ethyl acetate. A precipitate formed which was filtered, dried, and identified by NMR analysis as the desired product, m.p. 230°-235° C.

Workup

  1. customA precipitate formed which
  2. filtrationwas filtered
  3. customdried

Sources & evidence

ORD record
ord-6463fca92da8407191053f8bd5cb407d
Source dataset
uspto-grants-1985_04
Patent number
US04508722

Reaction notes

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