HCID 13502856, compound → HCID 13502857, compound

HRID 1980323Notes

Reaction equation

HRID 1980323 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([NH:8]C=O)[C:5]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:4][C:3]=1[C:16]1[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=1>C(O)C.Cl>[NH2:8][C:6]1[C:5]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:4][C:3]([C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)=[C:2]([Cl:1])[N:7]=1

Participants

4

Reactant 1

HCID 13502856HCID 13502856, compound

Product 1

HCID 13502857HCID 13502857, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidCatalystHCID 702EthanolSolvent

Procedure

6-Chloro-5-(4-chlorophenyl)-2-formamido-3-pyridinecarboxylic acid, ethyl ester (0.5 gram) was partially dissolved in 50 ml ethanol and treated with about 5-6 drops concentrated HCl. The reaction mixture was refluxed for approximately 3 hours, and upon cooling, a solid precipitate was collected, yield 350 mg, m.p. 195°-198° C.

Workup

  1. temperatureThe reaction mixture was refluxed for approximately 3 hours
  2. temperatureupon cooling
  3. customa solid precipitate was collected

Sources & evidence

ORD record
ord-4fbd020b503f4be483ad8ff7103c3416
Source dataset
uspto-grants-1985_04
Patent number
US04508722

Reaction notes

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