反应详情

A mixture of phenylacetone (13.4 grams) and dimethylformamide dimethylacetal (13.0 grams) was heated at 90°-95° C. on a steam bath for about 21/2 hours. A crude oil was produced which was then chromatographed on 600 ml of silica gel using ethyl acetate as an eluent. The final product, whose structure was confirmed by NMR, was a yellow oil which crystallized upon standing, yield 15.5 grams.

1. temperaturewas heated at 90°-95° C. on a steam bath for about 21/2 hours
2. customA crude oil was produced which
3. customwas then chromatographed on 600 ml of silica gel
4. customcrystallized