反应详情

It is contemplated that the foregoing product by reaction with phosgene and ethyl chloroformate can be converted to N-(3-chloro-4-methoxyphenyl)isatoic anhydride [VIII; R=H, R"=3--Cl, OR°=4--OCH3 ], and the latter reacted with piperidine to give 1-[2-(3-chloro-4-methoxyphenylamino)benzoyl]piperidine [IX; R=H, R"=3--Cl, N=Z=1-piperidinyl, OR°=4--OCH3 ] which can be de-etherified with boron tribromide to yield 1-[2-(3-chloro-4-hydroxyphenylamino)benzoyl]piperidine [I; R and R'=H, R"=3--Cl, N=Z=1-piperidinyl, OH at 4-position].