HCID 13392353, compound → HCID 13474602, compound

HRID 1980519Notes

Reaction equation

HRID 1980519 reaction equation
Cl[CH2:2][Si:3]([C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][C:7]=1[Cl:13])([CH3:5])[CH3:4].[Na].[NH:15]1[CH:19]=[N:18][CH:17]=[N:16]1>CN(C)C=O.O>[Cl:13][C:7]1[CH:8]=[C:9]([Cl:12])[CH:10]=[CH:11][C:6]=1[Si:3]([CH3:5])([CH3:4])[CH2:2][N:15]1[CH:19]=[N:18][CH:17]=[N:16]1

Participants

5

Reactant 2

HCID 13392353HCID 13392353, compoundHCID 454898221h-1,2,4-Triazole sodium salt

Product 1

HCID 13474602HCID 13474602, compoundYield 81%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

A mixture of 5.1 g (0.020 mol) of chloromethyl(2,4-dichlorophenyl)dimethysilane and 2.0 g (0.022 mol) of 1,2,4-triazole sodium salt in 10 ml of dry dimethylformamide was stirred at 80°-90° for 2 hours. The resulting slurry was cooled, diluted with water, and washed with ether. The ether extracts were washed with several portions of water and once with brine, dried over magnesium sulfate, and evaporated to leave 4.6 g (81%) of the title compound as a pale yellow liquid: nD23 1.5580; ir (neat) 1550, 1485, 1440, 1345, 1260, 1240, 1130, 1085, 1025, 1005, 835 cm-1 ; nmr (CDCl3) 0.5 (6H, s), 4.1 (2H, s), 7.2-7.5 (3H, m), 7.8 (1H, s), 7.9 (1H, s).

Workup

  1. temperatureThe resulting slurry was cooled
  2. washwashed with ether
  3. washThe ether extracts were washed with several portions of water and once with brine
  4. dry with materialdried over magnesium sulfate
  5. customevaporated

Sources & evidence

ORD record
ord-6dae36316219485db472dc7bd46be100
Source dataset
uspto-grants-1985_04
Patent number
US04510136

Reaction notes

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