Methanol → HCID 131714189, compound

Participants

Reaction Steps

A mixture of (1,1'-biphenyl-4-yl)chlorochloromethylmethylsilane and two equivalents of 1,2,4-triazole sodium salt in dimethylformamide is warmed to 80°-90° C. for 2 hours. Ten equivalents of methanol is then added, and the mixture is held at 70° C. for 1 hour, cooled, diluted with water, and quickly extracted with ether. Washing the ether solution with water and brine, drying over magnesium sulfate, and evaporation leaves the title compound.

Provenance & Evidence