Methanol → HCID 131714189, compound

HRID 1980524Notes

Reaction equation

HRID 1980524 reaction equation
[C:1]1([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][C:4]([Si:7](Cl)([CH2:9]Cl)[CH3:8])=[CH:3][CH:2]=1.[Na].[NH:19]1[CH:23]=[N:22][CH:21]=[N:20]1.[CH3:24][OH:25]>CN(C)C=O.O>[C:1]1([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][C:4]([SiH:7]([CH2:9][N:19]2[CH:23]=[N:22][CH:21]=[N:20]2)[CH2:8][O:25][CH3:24])=[CH:3][CH:2]=1

Participants

6

Reactant 3

HCID 887MethanolHCID 454898221h-1,2,4-Triazole sodium saltHCID 54452988HCID 54452988, compound

Product 1

HCID 131714189HCID 131714189, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

A mixture of (1,1'-biphenyl-4-yl)chlorochloromethylmethylsilane and two equivalents of 1,2,4-triazole sodium salt in dimethylformamide is warmed to 80°-90° C. for 2 hours. Ten equivalents of methanol is then added, and the mixture is held at 70° C. for 1 hour, cooled, diluted with water, and quickly extracted with ether. Washing the ether solution with water and brine, drying over magnesium sulfate, and evaporation leaves the title compound.

Workup

  1. temperatureis warmed to 80°-90° C. for 2 hours
  2. temperaturecooled
  3. extractionquickly extracted with ether
  4. washWashing the ether solution with water and brine
  5. dry with materialdrying over magnesium sulfate, and evaporation

Sources & evidence

ORD record
ord-36c7ce8166e14b8684800d2064603e50
Source dataset
uspto-grants-1985_04
Patent number
US04510136

Reaction notes

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