2-Chloroaniline → HCID 20401839, compound

HRID 1980554Notes

Reaction equation

HRID 1980554 reaction equation
Cl[C:2]1[C:7]([N:8]2[C:12]([CH2:13]Cl)=[N:11][C:10]([C:15]([OH:17])=[O:16])=[N:9]2)=[CH:6][CH:5]=[CH:4][N:3]=1.[Cl:18][C:19]1[CH:25]=[CH:24][CH:23]=[CH:22][C:20]=1[NH2:21]>>[Cl:18][C:19]1[CH:25]=[CH:24][CH:23]=[CH:22][C:20]=1[N:21]1[C:2]2[N:3]=[CH:4][CH:5]=[CH:6][C:7]=2[N:8]2[N:9]=[C:10]([C:15]([OH:17])=[O:16])[N:11]=[C:12]2[CH2:13]1

Participants

3

Reactant 2

HCID 72402-ChloroanilineHCID 13519249HCID 13519249, compound

Product 1

HCID 20401839HCID 20401839, compound

Procedure

using 31.40 g (0.115 mol) of 1-(2-chloro-3-pyridyl)-5-(chloromethyl)-1H-1,2,4-triazole-3-carboxylic acid and 206.00 g (1.61 mol) of 2-chloroaniline there is obtained 5-(2-chlorophenyl)-4,5-dihydropyrido[2,3-e][1,2,4]triazolo[1,5-a]pyrazine-2-carboxylic acid and the methyl ester thereof which, after recrystallisation from methylene chloride/isopropanol, melts at 155°-163°;

Sources & evidence

ORD record
ord-ea58859ce52943cb994aa2e293f7c2ab
Source dataset
uspto-grants-1985_04
Patent number
US04510141

Reaction notes

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