2-Chloroaniline → HCID 20401839, compound

Participants

Reaction Steps

using 31.40 g (0.115 mol) of 1-(2-chloro-3-pyridyl)-5-(chloromethyl)-1H-1,2,4-triazole-3-carboxylic acid and 206.00 g (1.61 mol) of 2-chloroaniline there is obtained 5-(2-chlorophenyl)-4,5-dihydropyrido[2,3-e][1,2,4]triazolo[1,5-a]pyrazine-2-carboxylic acid and the methyl ester thereof which, after recrystallisation from methylene chloride/isopropanol, melts at 155°-163°;

Provenance & Evidence