Cyclohexylamine → HCID 20401820, compound

HRID 1980557Notes

Reaction equation

HRID 1980557 reaction equation
Cl[C:2]1[C:7]([N:8]2[C:12]([CH2:13]Cl)=[N:11][C:10]([C:15]([OH:17])=[O:16])=[N:9]2)=[CH:6][CH:5]=[CH:4][N:3]=1.[CH:18]1([NH2:24])[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1>>[CH:18]1([N:24]2[C:2]3[N:3]=[CH:4][CH:5]=[CH:6][C:7]=3[N:8]3[N:9]=[C:10]([C:15]([OH:17])=[O:16])[N:11]=[C:12]3[CH2:13]2)[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 7965CyclohexylamineHCID 13519249HCID 13519249, compound

Product 1

HCID 20401820HCID 20401820, compound

Procedure

using 21.80 g (0.080 mol) of 1-(2-chloro-3-pyridyl)-5-(chloromethyl)-1H-1,2,4-triazole-3-carboxylic acid and 35.70 g (0.360 mol) of cyclohexylamine there is obtained 5-cyclohexyl-4,5-dihydropyrido[2,3-e][1,2,4]triazolo[1,5-a]pyrazine-2-carboxylic acid and the methyl ester thereof which, after recrystallisation from methylene chloride/isopropanol, melts at 170°-176°.

Sources & evidence

ORD record
ord-6468f6b269894e54ad8584ca310158d3
Source dataset
uspto-grants-1985_04
Patent number
US04510141

Reaction notes

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