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HRID1980633

反应详情

EQUATION

反应方程式

HRID 1980633 的结构方程式

REACTANTS

反应物

2
结构：Cc1ccc(S(=O)(=O)O)cc1.O
HCID521998

4-Methylbenzenesulfonic acid hydrate

C7H10O4S

结构：C=CCS(=O)C1CC(=O)N1C(C(=O)OCOC(=O)C(C)(C)C)=C(SC(C)=O)SC(C)=O
HCID20275777

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)SC1=C(C(=O)OCOC(=O)C(C)(C)C)N2C(=O)CC2SS1
HCID20275776

未命名化合物

收率 54%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1COCCO1
溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

A solution of 82 mg of pivaloyloxymethyl 3,3-di(acetylthio)-2-(4-allylsulphinylazetidin-2-on-1-yl)propenoate and 32 mg of 4-toluenesulphonic acid hydrate in 10 ml of dioxan was heated rapidly to reflux and maintained under reflux for 1 hour. The solvent was removed by evaporation and the residue chromatographed on silica gel using ethyl acetate/hexane mixtures as eluant. The product (35 mg, 54%) was obtained as a yellow oil.

WORKUP

后处理

  1. temperatureto reflux
  2. temperaturemaintained
  3. temperatureunder reflux for 1 hour
  4. customThe solvent was removed by evaporation
  5. customthe residue chromatographed on silica gel