Cysteamine Hydrochloride → HCID 20402134, compound

HRID 1980724Notes

Reaction equation

HRID 1980724 reaction equation
[ClH:1].[NH2:2][CH2:3][CH2:4][SH:5].[Cl:6][CH2:7][C:8]1[N:9]=[C:10]([NH:13][C:14]([NH:17][CH3:18])=[N:15][CH3:16])[S:11][CH:12]=1>Cl>[ClH:6].[ClH:1].[CH3:16][N:15]=[C:14]([NH:17][CH3:18])[NH:13][C:10]1[S:11][CH:12]=[C:8]([CH2:7][S:5][CH2:4][CH2:3][NH2:2])[N:9]=1

Participants

4

Reactant 2

HCID 9082Cysteamine HydrochlorideHCID 20402023HCID 20402023, compound

Product 1

HCID 20402134HCID 20402134, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Cysteamine hydrochloride (2.25 g; 19.6 mmoles) and 4-chloromethyl-2-(2,3-dimethylguanidino)thiazole (5 g; 19.6 mmoles) [prepared from 1,3-dichloro-2- propanone and (N,N'-dimethylamidino)thiourea which is itself prepared from dimethyl cyanodithioiminocarbonate and methylamine] were dissolved in 17.5 ml of concentrated hydrochloric acid and heated at an oil bath temperature of 100°. After 24 hours the reaction mixture was evaporated under reduced pressure and the residue crystallized from absolute ethanol to yield the title compound, mp 243°-245°.

Workup

  1. temperatureheated at an oil bath temperature of 100°
  2. customAfter 24 hours the reaction mixture was evaporated under reduced pressure
  3. customthe residue crystallized from absolute ethanol

Sources & evidence

ORD record
ord-d6b9323355ca42ab98ba9654e122bce2
Source dataset
uspto-grants-1985_04
Patent number
US04510309

Reaction notes

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