Cysteamine Hydrochloride → HCID 20402201, compound

HRID 1980727Notes

Reaction equation

HRID 1980727 reaction equation
[ClH:1].[NH2:2][CH2:3][CH2:4][SH:5].Cl.[NH2:7][C:8]1[S:9][CH:10]=[C:11]([CH2:13][Cl:14])[N:12]=1>Cl>[ClH:14].[ClH:1].[NH2:7][C:8]1[S:9][CH:10]=[C:11]([CH2:13][S:5][CH2:4][CH2:3][NH2:2])[N:12]=1

Participants

4

Reactant 2

HCID 9082Cysteamine HydrochlorideHCID 732282-Thiazolamine, 4-(chloromethyl)-, hydrochloride (1:1)

Product 1

HCID 20402201HCID 20402201, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Cysteamine hydrochloride (5.65 g; 50.0 mmoles) and 2-amino-4-chloromethylthiazole hydrochloride (9.25 g; 50.0 mmoles) were dissolved in 70 ml of concentrated hydrochloric acid and heated at an oil bath temperature of 105°. After 64 hours of heating the mixture was evaporated under reduced pressure and the residue triturated with acetone. The collected product was re-triturated with ethanol, filtered and dried to yield the title compound, mp 170°-200°.

Workup

  1. temperatureheated at an oil bath temperature of 105°
  2. temperatureAfter 64 hours of heating the mixture
  3. customwas evaporated under reduced pressure
  4. customthe residue triturated with acetone
  5. customThe collected product was re-triturated with ethanol
  6. filtrationfiltered
  7. customdried

Sources & evidence

ORD record
ord-0dd4649faa214ac7a5a58905f7e4ac49
Source dataset
uspto-grants-1985_04
Patent number
US04510309

Reaction notes

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