反应详情

A mixture of 2.0 g of ethyl o-methylbenzoate (12.2 m mol), 1.62 g of 4-aminoindan (12.2 m mol), 0.72 g of CH3ONa and 30 ml of benzene is stirred for 10 hours under reflux. After ice-cooling, the mixture is added to dilute hydrochloric acid and extracted with ethyl acetate. The organic layer is washed with water and concentrated. The resulting crystals are washed with n-hexane to give 2.0 g of N-4-indanyl-o-methylbenzamide (yield: 65.4%).

1. temperatureunder reflux
2. temperatureAfter ice-cooling
3. extractionextracted with ethyl acetate
4. washThe organic layer is washed with water
5. concentrationconcentrated
6. washThe resulting crystals are washed with n-hexane