Hydrochloric Acid → HCID 20400825, compound

HRID 1980849Notes

Reaction equation

HRID 1980849 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[NH:8][C:9]3[C:14]([C:15]=2[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]([O:23]CC)=[O:22])=[CH:13][CH:12]=[CH:11][CH:10]=3)[CH:2]=1.[ClH:26]>>[ClH:26].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[NH:8][C:9]3[C:14]([C:15]=2[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]([OH:23])=[O:22])=[CH:13][CH:12]=[CH:11][CH:10]=3)[CH:2]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 13424120HCID 13424120, compound

Product 1

HCID 20400825HCID 20400825, compound

Procedure

A solution of 7.46 g of 2-(3-pyridyl)-3-[5-(ethoxycarbonyl)-pentyl]-indole in 2N aqueous hydrochloric acid (275 ml) is heated at reflux for 20 hours. The hot reaction mixture is filtered, and the filtrate on cooling gives yellow crystals which are collected by filtration and dried to yield 2-(3-pyridyl)-3-(5-carboxypentyl)-indole hydrochloride, m.p. 220°-222°.

Workup

  1. temperatureat reflux for 20 hours
  2. filtrationThe hot reaction mixture is filtered
  3. temperaturethe filtrate on cooling
  4. customgives yellow crystals which
  5. filtrationare collected by filtration
  6. customdried

Sources & evidence

ORD record
ord-a2a6cc971b814b0e9fd4b8690badf8ab
Source dataset
uspto-grants-1985_04
Patent number
US04511573

Reaction notes

Loading…