HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 3-[2-(4-Carboxyphenoxy)-ethyl]-2-(3-pyridyl)-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-[2-(4-Ethoxycarbonylphenoxy)ethyl]-2-(3-pyridyl)-indole | HCID 20400790 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 3-[2-(4-Carboxyphenoxy)-ethyl]-2-(3-pyridyl)-indole | HCID 20400814 | — |
Reaction Steps
A mixture of 4.5 g of 3-[2-(4-ethoxycarbonylphenoxy)ethyl]-2-(3-pyridyl)-indole in 220 ml of 2N hydrochloric acid is heated under reflux for 6 hours. After cooling the solution is made basic with 3N NaOH and extracted with ethyl acetate. The basic solution is filtered and acidifed to pH 6-7 with 3N NCl. The solid is collected and dried to give 3-[2-(4-carboxyphenoxy)-ethyl]-2-(3-pyridyl)-indole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04511573 |
| Source dataset | uspto-grants-1985_04 |
| ORD ID | ord-fc974d9019c74f519b43c5ba1b849340 |
| Source note | uspto-grants-1985_04 |