反应详情

A mixture of 4.5 g of 3-[2-(4-ethoxycarbonylphenoxy)ethyl]-2-(3-pyridyl)-indole in 220 ml of 2N hydrochloric acid is heated under reflux for 6 hours. After cooling the solution is made basic with 3N NaOH and extracted with ethyl acetate. The basic solution is filtered and acidifed to pH 6-7 with 3N NCl. The solid is collected and dried to give 3-[2-(4-carboxyphenoxy)-ethyl]-2-(3-pyridyl)-indole.

1. temperatureis heated
2. temperatureunder reflux for 6 hours
3. temperatureAfter cooling the solution
4. extractionextracted with ethyl acetate
5. filtrationThe basic solution is filtered
6. customThe solid is collected
7. customdried