Sodium Hydroxide → Triphenylphosphine Oxide

Participants

Reaction Steps

To a mixture of isobutanol (50 ml), triphenylphosphine sulfide (7.0 g) and aqueous 5% sodium hydroxide (50 ml) is bubbled chlorine gas at 15° C. until no appreciable amount of the starting sulfide is detected on thin-layer chromatogram. The reaction mixture is allowed to stand for a while and the organic layer is taken. The layer is washed with water and concentrated to dryness. The residue is triturated with ether to give triphenylphosphine oxide.

Provenance & Evidence