Diethyl Ether → HCID 13472124, compound

HRID 1981132Notes

Reaction equation

HRID 1981132 reaction equation
[CH3:1][N:2]([CH3:20])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]([N:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:13][CH2:12][CH2:11]1)=O.[H-].[Al+3].[Li+].[H-].[H-].[H-].CCOCC>O>[CH3:20][N:2]([CH3:1])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][N:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:13][CH2:12][CH2:11]1

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 13472123HCID 13472123, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 13472124HCID 13472124, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The 1-(6-dimethylaminohexanoyl)-1,2,3,4-tetrahydroquinoline (4.0 g) was added to a mixture of lithium aluminium hydride (1.4 g) and ether (200 ml). The mixture was refluxed for 5 hours, then cooled. Water was added cautiously, and the organic solution was separated, dried and evaporated to give the title compound as an oil which is then converted to the dihydrochloride, mp 116°-119°.

Workup

  1. temperatureThe mixture was refluxed for 5 hours
  2. temperaturecooled
  3. customthe organic solution was separated
  4. customdried
  5. customevaporated

Sources & evidence

ORD record
ord-f09530103625453d84586d349e53f201
Source dataset
uspto-grants-1985_04
Patent number
US04512990

Reaction notes

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