Water → HCID 13472126, compound

HRID 1981136Notes

Reaction equation

HRID 1981136 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]([N:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11][CH2:10][CH2:9]1)=O.[H-].[Al+3].[Li+].[H-].[H-].[H-].O>CCOCC>[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][N:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11][CH2:10][CH2:9]1

Participants

5

Reactant 3

HCID 962WaterHCID 20399855HCID 20399855, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 13472126HCID 13472126, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The 1-(5-hydroxypentanoyl)-1,2,3,4-tetrahydroquinoline (2.0 g) was refluxed for 8 hours in ether (250 ml) containing lithium aluminium hydride (1.0 g). The solution was cooled, water was added, and the ethereal solution was extracted with dilute hydrochloric acid. The extract was basified with sodium hydroxide and extracted with ether. The ethereal solution was dried and evaporated to afford the title compound as an oil.

Workup

  1. temperatureThe solution was cooled
  2. extractionthe ethereal solution was extracted with dilute hydrochloric acid
  3. extractionextracted with ether
  4. customThe ethereal solution was dried
  5. customevaporated

Sources & evidence

ORD record
ord-43dc1c5a2ada418d922fe24bcd7d290c
Source dataset
uspto-grants-1985_04
Patent number
US04512990

Reaction notes

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