(3S)-3-Benzoylamino-1-chloro-4-phenyl-2-butanone → 4-oxo-1,5-benzothiazepine-5(2H)-acetic acid, ethyl ester

HRID 1981142Notes

Reaction equation

HRID 1981142 reaction equation
N[CH:2]1[C:8](=[O:9])[N:7]([CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:6]2[CH:16]=[CH:17][CH:18]=[CH:19][C:5]=2[S:4][CH2:3]1.ClCC(=O)[C@@H](NC(=O)C1C=CC=CC=1)CC1C=CC=CC=1>>[O:9]=[C:8]1[N:7]([CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:6]2[CH:16]=[CH:17][CH:18]=[CH:19][C:5]=2[S:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 13339657(3S)-3-Benzoylamino-1-chloro-4-phenyl-2-butanoneHCID 15591257(+/-)-3-amino-3,4-dihydro-4-oxo-1,5-benzothiazepine-5(2H)-acetic acid, ethyl ester

Product 1

HCID 867400334-oxo-1,5-benzothiazepine-5(2H)-acetic acid, ethyl ester

Procedure

(±)-3-Amino-3,4-dihydro-4-oxo-1,5-benzothiazepine-5(2H)-acetic acid, ethyl ester is reacted with (S)-N-[3-chloro-2-oxo-1-(phenylmethyl)propyl]benzamide according to the procedure of Example 1(h) to yield (±)-dihydro-3-[[3-benzoylamino)-2-oxo-4-phenylbutyl]amino]-4-oxo-1,5-benzothiazepine-5(2H)-acetic acid, ethyl ester.

Sources & evidence

ORD record
ord-a9ad7b8a8c8a498db8e7835307e2d23c
Source dataset
uspto-grants-1985_04
Patent number
US04512988

Reaction notes

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