Methanethiol → 50648-53-8

HRID 1981153Notes

Reaction equation

HRID 1981153 reaction equation
[S:1]([OH:5])([OH:4])(=[O:3])=[O:2].[CH3:6][NH:7][C:8](=[NH:10])S.OCC[NH:14]C.CS.[CH:18]([OH:21])(C)[CH3:19]>C(O)C>[S:1]([OH:5])([OH:4])(=[O:3])=[O:2].[OH:21][CH2:18][CH2:19][N:7]([CH3:6])[C:8]([NH2:10])=[NH:14]

Participants

6

Reactant 4

HCID 878MethanethiolHCID 3776IsopropanolHCID 80162-(Methylamino)ethanolHCID 178485225HCID 178485225, compound

Product 1

HCID 2039989650648-53-8

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The above intermediate N-(2-hydroxyethyl)-N-methylquanidine sulfate was prepared as follows: A mixture containing 83.6 g of methyl isothiourea sulfate and 90 g of N-(2-hydroxyethyl)methylamine was heated on a steam bath under vacuum until no more methyl mercaptan was evolved. The solid remaining was boiled successively with hot isopropyl alcohol, hot absolute ethanol and then ether, and collected to yield 91 g of crystalline N-(2-hydroxyethyl)-N-methylguanidine sulfate.

Workup

  1. customether, and collected

Sources & evidence

ORD record
ord-f46e361758fc4810b257df44f7b9c0a6
Source dataset
uspto-grants-1985_04
Patent number
US04512993

Reaction notes

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