2-Amino-4,6-dimethoxypyrimidine → 2-(1,2,3-Thiadiazol-4-yl)phenyl N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]sulfamate

HRID 1981264Notes

Reaction equation

[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[CH:5]=[C:4]([O:10][CH3:11])[N:3]=1.[N:12]([S:15]([O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[C:25]1[N:26]=[N:27][S:28][CH:29]=1)(=[O:17])=[O:16])=[C:13]=[O:14]>O1CCCC1>[CH3:9][O:8][C:6]1[CH:5]=[C:4]([O:10][CH3:11])[N:3]=[C:2]([NH:1][C:13]([NH:12][S:15](=[O:17])(=[O:16])[O:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[C:25]2[N:26]=[N:27][S:28][CH:29]=2)=[O:14])[N:7]=1

Participants

Conditions

Temperature: 25 °C

Procedure

By the procedure of Example 4, 5.3 g of 2-amino-4,6-dimethoxypyrimidine in 20 ml of tetrahydrofuran was reacted with 14 g of the isocyanate prepared in Example 5 above in 30 ml of tetrahydrofuran. After stirring the mixture at 25° C. for 3 hours, the mixture was filtered and the solid isolated was recrystallized from acetonitrile to yield 4 g of the title compound; m.p. 173°-175° C.

Workup

filtrationthe mixture was filtered
customthe solid isolated
customwas recrystallized from acetonitrile

Sources & evidence

ORD record: ord-622200eec1624ee59036a252bcc12138
Source dataset: uspto-grants-1985_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04514214

Reaction notes

Loading…