反应详情

To a solution of 18.0 g of 7-amino-2,3-dihydro-2-methylbenzo[b]thiophene (Example 7) in 100 ml of 1-chlorobutane was added a solution of 13.0 ml of acetic anhydride in 20 ml of 1-chlorobutane. After the exothermic reaction subsided, the mixture was refluxed for 0.3 hour, cooled in an ice-bath and filtered. The isolated solid was washed with 1-chlorobutane to yield 15.2 g of the title compound; m.p. 125°-127° C.

1. customAfter the exothermic reaction
2. temperaturethe mixture was refluxed for 0.3 hour
3. temperaturecooled in an ice-bath
4. filtrationfiltered
5. washThe isolated solid was washed with 1-chlorobutane