Methyl 2-(1-benzylpyrrolidin-3-yl)acetate → Methyl 2-(pyrrolidin-3-yl)acetate

HRID 1981325Notes

Reaction equation

HRID 1981325 reaction equation
C([N:8]1[CH2:12][CH2:11][CH:10]([CH2:13][C:14]([O:16][CH3:17])=[O:15])[CH2:9]1)C1C=CC=CC=1>[Pd].C(O)C>[NH:8]1[CH2:12][CH2:11][CH:10]([CH2:13][C:14]([O:16][CH3:17])=[O:15])[CH2:9]1

Participants

4

Reactant 1

HCID 4287640Methyl 2-(1-benzylpyrrolidin-3-yl)acetate

Product 1

HCID 13424175Methyl 2-(pyrrolidin-3-yl)acetate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

The above prepared methyl 1-benzyl-3-pyrrolidineacetate hexamate was reduced in three portions, using 3.9 g. of 10% palladium on carbon in 200 ml. of absolute ethanol, for one hour at 50° C. The reaction mixture was filtered and concentrated to give methyl 3-pyrrolidineacetate hexamate, m.p. 68.5°-69.5° C.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-602380c5ea2d4a12abe6184b0d009ee8
Source dataset
uspto-grants-1985_04
Patent number
US04514414

Reaction notes

Loading…