Methylhydrazine → 1-amino-3-(4-chlorophenyl)-1-methylthiourea

HRID 1981335Notes

Reaction equation

HRID 1981335 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]=[C:9]=[S:10])=[CH:4][CH:3]=1.[CH3:11][NH:12][NH2:13]>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([N:12]([CH3:11])[NH2:13])=[S:10])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6061MethylhydrazineHCID 164804-Chlorophenyl isothiocyanate

Product 1

HCID 20609161-amino-3-(4-chlorophenyl)-1-methylthiourea

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 4-chlorophenylisothiocyanate (17.0 g, 0.10 mole) and methylhydrazine (5.0 g, 0.11 mole) in 80 ml of ethanol was stirred at room temperature for two hours. The reaction mixture was filtered to collect colorless crystalline N-(4-chlorophenyl)-1-methylhydrazinecarbothioamide (18.4 g, mp 152°-154° C.).

Workup

  1. filtrationThe reaction mixture was filtered
  2. customto collect colorless crystalline N-(4-chlorophenyl)-1-methylhydrazinecarbothioamide (18.4 g, mp 152°-154° C.)

Sources & evidence

ORD record
ord-6d4d2704efcb46fc958055c8e078625f
Source dataset
uspto-grants-1985_04
Patent number
US04514419

Reaction notes

Loading…