HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Hydroxybenzaldehyde → 3-{3-[(Thiomorpholin-4-yl)methyl]phenoxy}propan-1-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Hydroxybenzaldehyde | HCID 101 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Thiomorpholine | HCID 67164 | — |
| Reactant | Phenol, 3-(4-thiomorpholinylmethyl)- | HCID 763337 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 1-Propanamine, 3-chloro-, hydrochloride | HCID 11469095 | — |
| Product | 3-{3-[(Thiomorpholin-4-yl)methyl]phenoxy}propan-1-amine | HCID 20151506 | — |
Reaction Steps
By operating as described hereinabove, by reacting 0.2 mol of 3-hydroxybenzaldehyde with 0.4 mol of thiomorpholine in the presence of 0.2 mol of sodium borohydride (as in PREPARATION 1(a) 3-thiomorpholinomethylphenol is obtained, which, treated with an excess of 3-chloropropylamine hydrochloride in the presence of sodium hydride (as in PREPARATION 1(b), gives 3-(3-thiomorpholinomethylphenoxy)propylamine, in the form of an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04514408 |
| Source dataset | uspto-grants-1985_04 |
| ORD ID | ord-56be3c1587b541558e18dc19dd2b92a3 |
| Source note | uspto-grants-1985_04 |