Ammonia → α-Phenyl-2-benzothiazolemethanamine

HRID 1981460Notes

Reaction equation

HRID 1981460 reaction equation
Cl.[NH2:2][CH:3]([C:10]1[S:11][C:12]2[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=2[N:14]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.N>C(Cl)Cl>[NH2:2][CH:3]([C:10]1[S:11][C:12]2[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=2[N:14]=1)[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 23318519HCID 23318519, compound

Product 1

HCID 13342005α-Phenyl-2-benzothiazolemethanamine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The hydrochloride was stirred with aqueous ammonia and methylene chloride, and the aqueous layer was extracted with two portions of methylene chloride. The combined methylene chloride extracts were washed with brine, dried over Na2SO4, filtered and concentrated in vacuo. 13.1 g of white solid, as desired product, was obtained, mp. 68°-70° C.

Workup

  1. extractionthe aqueous layer was extracted with two portions of methylene chloride
  2. washThe combined methylene chloride extracts were washed with brine
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-5808603c1b1743d2b9708677bca3ab96
Source dataset
uspto-grants-1986_06
Patent number
US04592774

Reaction notes

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