4-Aminobenzoic Acid → HCID 13326883, compound

HRID 1981472Notes

Reaction equation

HRID 1981472 reaction equation
O[CH:2]([OH:18])[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=1)=[O:4].[NH2:19][C:20]1[CH:28]=[CH:27][C:23]([C:24]([OH:26])=[O:25])=[CH:22][CH:21]=1.[C:29]1(C)C=CC=C[CH:30]=1>>[CH2:29]([O:18][CH:2]([NH:19][C:20]1[CH:28]=[CH:27][C:23]([C:24]([OH:26])=[O:25])=[CH:22][CH:21]=1)[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:6]=1)=[O:4])[CH3:30]

Participants

4

Reactant 3

HCID 9784-Aminobenzoic AcidHCID 1140TolueneHCID 13326882HCID 13326882, compound

Product 1

HCID 13326883HCID 13326883, compound

Conditions

Temperature
0 °C

Procedure

A 5.1 g. portion of 2,2-dihydroxy-1-[(3-phenoxy)phenyl]ethanone and 2.75 g. of p-aminobenzoic acid in 40 ml. of toluene was refluxed under argon for one hour, then cooled and evaporated to dryness. The residue was added to 40 ml. of ethanol and refluxed for 30 minutes, then cooled to 0° C., giving the desired product, m.p. 117°-127° C. (dec.).

Workup

  1. temperaturecooled
  2. customevaporated to dryness
  3. additionThe residue was added to 40 ml
  4. temperatureof ethanol and refluxed for 30 minutes

Sources & evidence

ORD record
ord-01e14b9ccc2c48a29fc792f6cf13cc35
Source dataset
uspto-grants-1986_06
Patent number
US04592876

Reaction notes

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