Triethylamine → HCID 86741471, compound

HRID 1981503Notes

Reaction equation

HRID 1981503 reaction equation
[CH:1]1[N:6]=[C:5](Cl)[C:4]2[N:8]=[CH:9][N:10]([C@@H:11]3[O:15][C@H:14]([CH2:16][OH:17])[C@@H:13]([OH:18])[C@H:12]3[OH:19])[C:3]=2[N:2]=1.[C:20]1([CH2:33][CH2:34][NH2:35])[C:32]2[CH2:31][C:30]3[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=3)[C:24]=2[CH:23]=[CH:22][CH:21]=1.C(N(CC)CC)C>C(O)C>[C:20]1([CH2:33][CH2:34][NH:35][C:5]2[C:4]3[N:8]=[CH:9][N:10]([C:3]=3[N:2]=[CH:1][N:6]=2)[C@@H:11]2[O:15][C@H:14]([CH2:16][OH:17])[C@@H:13]([OH:18])[C@H:12]2[OH:19])[C:32]2[CH2:31][C:30]3[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=3)[C:24]=2[CH:23]=[CH:22][CH:21]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 930036-Chloropurine ribosideHCID 15212223HCID 15212223, compound

Product 1

HCID 86741471HCID 86741471, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A reaction mixture of 1.75 g of 6-chlorpurine riboside, 1.78 g of fluorenylethylamine and 1.84 g of triethylamine is refluxed in 50 ml of ethanol under nitrogen for 20 hrs. Upon cooling, solid material crystallizes out. It is filtered and dried affording 2.75 g (95%) of N6 -fluorenylethyl adenosine having a melting point of 120°-123° C.

Workup

  1. temperatureUpon cooling
  2. customsolid material crystallizes out
  3. filtrationIt is filtered
  4. customdried

Sources & evidence

ORD record
ord-2a59d8188e034bd1b30c7e4442e864b0
Source dataset
uspto-grants-1986_06
Patent number
US04593019

Reaction notes

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