Sodium Hydroxide → 3-(3-Methoxyphenyl)piperidine

HRID 1981551Notes

Reaction equation

HRID 1981551 reaction equation
[OH-].[Na+].Cl.[CH3:4][O:5][C:6]1[CH:7]=[C:8]([CH:12]2[CH2:17][CH2:16][CH2:15][NH:14][CH2:13]2)[CH:9]=[CH:10][CH:11]=1>ClCCl>[CH3:4][O:5][C:6]1[CH:7]=[C:8]([CH:12]2[CH2:17][CH2:16][CH2:15][NH:14][CH2:13]2)[CH:9]=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 199872553-(3-Methoxyphenyl)piperidine hydrochloride

Product 1

HCID 110742303-(3-Methoxyphenyl)piperidineYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred mixture of 100 ml of 10% aqueous sodium hydroxide and 100 ml of dichloromethane was added 15 g of 3-(3-methoxyphenyl)piperidine hydrochloride. After a few minutes, the layers were separated and the organic layer was dried using potassium carbonate. Evaporation of the dichloromethane solution then afforded 12.6 g of the title compound as an oil.

Workup

  1. waitAfter a few minutes
  2. customthe layers were separated
  3. customthe organic layer was dried
  4. customEvaporation of the dichloromethane solution

Sources & evidence

ORD record
ord-fa47cb3333874528902af4acb39a8dc9
Source dataset
uspto-grants-1986_06
Patent number
US04593037

Reaction notes

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