HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 3-(3-Methoxyphenyl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-(3-Methoxyphenyl)piperidine hydrochloride | HCID 19987255 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-(3-Methoxyphenyl)piperidine | HCID 11074230 | 100% |
Reaction Steps
To a stirred mixture of 100 ml of 10% aqueous sodium hydroxide and 100 ml of dichloromethane was added 15 g of 3-(3-methoxyphenyl)piperidine hydrochloride. After a few minutes, the layers were separated and the organic layer was dried using potassium carbonate. Evaporation of the dichloromethane solution then afforded 12.6 g of the title compound as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04593037 |
| Source dataset | uspto-grants-1986_06 |
| ORD ID | ord-fa47cb3333874528902af4acb39a8dc9 |
| Source note | uspto-grants-1986_06 |