Potassium Carbonate → HCID 135668094, compound

HRID 1981565Notes

Reaction equation

HRID 1981565 reaction equation
Cl.[N:2]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14]2[CH:15]=[C:16]3[C:21](=[CH:22][CH:23]=2)[N:20]=[C:19]2[NH:24][C:25](=[O:27])[CH2:26][N:18]2[CH2:17]3)[CH:6]=[CH:5][N:4]=[CH:3]1.C(=O)([O-])[O-].[K+].[K+]>CCOCC>[N:2]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14]2[CH:15]=[C:16]3[C:21](=[CH:22][CH:23]=2)[N:20]=[C:19]2[NH:24][C:25](=[O:27])[CH2:26][N:18]2[CH2:17]3)[CH:6]=[CH:5][N:4]=[CH:3]1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 136332144HCID 136332144, compound

Product 1

HCID 135668094HCID 135668094, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

1.0 g of 7-(6-(N-imidazolyl)hexyl)oxy-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-one HCl suspended in 50 ml of ether is stirred with a twofold stoichiometric excess of dilute aqueous potassium carbonate solution until the salt is completely dissolved. The organic layer is then separated, washed twice with water, dried over magnesium sulfate and evaporated to yield 7-(6-(N-imidazolyl)hexyl)oxy-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-one as the free base.

Workup

  1. dissolutionis completely dissolved
  2. customThe organic layer is then separated
  3. washwashed twice with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated

Sources & evidence

ORD record
ord-18f751fe37854ee5b69da563374c8b62
Source dataset
uspto-grants-1986_06
Patent number
US04593029

Reaction notes

Loading…