1,4-Bis(phenylmethyl)piperazinone, hydrochloride → 1-Benzylpiperazin-2-one hydrochloride

HRID 1981610Notes

Reaction equation

HRID 1981610 reaction equation
[ClH:1].[C:2]1([CH2:8][N:9]2[CH2:14][CH2:13][N:12](CC3C=CC=CC=3)[CH2:11][C:10]2=[O:22])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H][H]>C(O)C.[Pd]>[ClH:1].[C:2]1([CH2:8][N:9]2[CH2:14][CH2:13][NH:12][CH2:11][C:10]2=[O:22])[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 233196591,4-Bis(phenylmethyl)piperazinone, hydrochlorideHCID 178418361HCID 178418361, compound2×

Product 1

HCID 127445191-Benzylpiperazin-2-one hydrochloride

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 1,4-bis(phenylmethyl)piperazinone hydrochloride (XIII, Example 39, 15.0 g.) and 10% palladium charcoal (5.0 g.) in ethanol (200 ml.) is hydrogenated (50 lb. initial hydrogen pressure) until uptake of hydrogen ceased. The solution is filtered, the ethanol is removed under reduced pressure and the residual solid is recrystallized from methanol-isopropanol to give the title compound, m.p. 160°-161°.

Workup

  1. filtrationThe solution is filtered
  2. customthe ethanol is removed under reduced pressure
  3. customthe residual solid is recrystallized from methanol-isopropanol

Sources & evidence

ORD record
ord-a253f7ed7e4c4267b42446cb860be29e
Source dataset
uspto-grants-1986_06
Patent number
US04593098

Reaction notes

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