HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Bis(phenylmethyl)piperazinone, hydrochloride → 1-Benzylpiperazin-2-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Bis(phenylmethyl)piperazinone, hydrochloride | HCID 23319659 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-Benzylpiperazin-2-one hydrochloride | HCID 12744519 | — |
Reaction Steps
A mixture of 1,4-bis(phenylmethyl)piperazinone hydrochloride (XIII, Example 39, 15.0 g.) and 10% palladium charcoal (5.0 g.) in ethanol (200 ml.) is hydrogenated (50 lb. initial hydrogen pressure) until uptake of hydrogen ceased. The solution is filtered, the ethanol is removed under reduced pressure and the residual solid is recrystallized from methanol-isopropanol to give the title compound, m.p. 160°-161°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04593098 |
| Source dataset | uspto-grants-1986_06 |
| ORD ID | ord-a253f7ed7e4c4267b42446cb860be29e |
| Source note | uspto-grants-1986_06 |