1-Methyl-3-(2-methylpropyl)-4-(phenylmethyl)piperazinone → 3-Isobutyl-1-methyl-piperazin-2-one

HRID 1981617Notes

Reaction equation

HRID 1981617 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5](CC2C=CC=CC=2)[CH:4]([CH2:15][CH:16]([CH3:18])[CH3:17])[C:3]1=[O:19].[H][H]>CO.[Pd]>[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH:4]([CH2:15][CH:16]([CH3:17])[CH3:18])[C:3]1=[O:19]

Participants

5

Reactant 2

HCID 233196871-Methyl-3-(2-methylpropyl)-4-(phenylmethyl)piperazinoneHCID 178418361HCID 178418361, compound2×

Product 1

HCID 233196533-Isobutyl-1-methyl-piperazin-2-one

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

1-Methyl-3-(2-methylpropyl-4-(phenylmethyl)piperazinone (Example 47, 2.1 g.) is dissolved in methanol (200 ml.), 10% palladium charcoal (1.0 g.) is added and the product is hydrogenated (50 lb. initial hydrogen pressure until the uptake of hydrogen ceased. The solution is filtered and the methanol is removed under reduced pressure to give the title compound as an oil.

Workup

  1. filtrationThe solution is filtered
  2. customthe methanol is removed under reduced pressure

Sources & evidence

ORD record
ord-364bc7cfd25b4a729de34eeee00d4cfd
Source dataset
uspto-grants-1986_06
Patent number
US04593098

Reaction notes

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