HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-3-(2-methylpropyl)-4-(phenylmethyl)piperazinone → 3-Isobutyl-1-methyl-piperazin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-3-(2-methylpropyl)-4-(phenylmethyl)piperazinone | HCID 23319687 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-Isobutyl-1-methyl-piperazin-2-one | HCID 23319653 | — |
Reaction Steps
1-Methyl-3-(2-methylpropyl-4-(phenylmethyl)piperazinone (Example 47, 2.1 g.) is dissolved in methanol (200 ml.), 10% palladium charcoal (1.0 g.) is added and the product is hydrogenated (50 lb. initial hydrogen pressure until the uptake of hydrogen ceased. The solution is filtered and the methanol is removed under reduced pressure to give the title compound as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04593098 |
| Source dataset | uspto-grants-1986_06 |
| ORD ID | ord-364bc7cfd25b4a729de34eeee00d4cfd |
| Source note | uspto-grants-1986_06 |