Ethyl 2-acetamido-3-benzylaminobutyrate → Ethyl 2-acetamido-3-aminobutyrate

HRID 1981638Notes

Reaction equation

HRID 1981638 reaction equation
[C:1]([NH:4][CH:5]([CH:11]([NH:13]CC1C=CC=CC=1)[CH3:12])[C:6]([O:8][CH2:9][CH3:10])=[O:7])(=[O:3])[CH3:2].[H][H]>C(O)C.[Pd]>[C:1]([NH:4][CH:5]([CH:11]([NH2:13])[CH3:12])[C:6]([O:8][CH2:9][CH3:10])=[O:7])(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 13592826Ethyl 2-acetamido-3-benzylaminobutyrateHCID 178418361HCID 178418361, compound2×

Product 1

HCID 23319786Ethyl 2-acetamido-3-aminobutyrateYield 100%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Five grams of ethyl 2-acetamido-3-benzylaminobutyrate were dispersed in 20 ml of ethanol together with 0.5 of 5% palladium-on-carbon and shaken under 40 psi of hydrogen until hydrogen uptake had ceased. The mixture was filtered through Celite and evaporated to give a 100% yield of ethyl 2-acetamido-3-aminobutyrate.

Workup

  1. filtrationThe mixture was filtered through Celite
  2. customevaporated

Sources & evidence

ORD record
ord-1240d6c20d4641eaaaa2a6f34dded9c5
Source dataset
uspto-grants-1986_06
Patent number
US04593118

Reaction notes

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