Propylamine → HCID 23317810, compound

HRID 1981837Notes

Reaction equation

HRID 1981837 reaction equation
[CH2:1]([NH2:4])[CH2:2][CH3:3].[CH3:5][P:6]([CH3:13])([CH:8]([OH:12])[C:9]([OH:11])=[O:10])=[O:7]>O>[CH3:5][P:6]([CH3:13])([CH:8]([OH:12])[C:9]([O-:11])=[O:10])=[O:7].[CH2:1]([NH3+:4])[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 7852PropylamineHCID 119559(Dimethylphosphoryl)(hydroxy)acetic acid

Product 1

HCID 23317810HCID 23317810, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
25 °C

Procedure

8.9 g (0.15 mol) of propylamine are added dropwise to a solution of 15.2 g (0.1 mol) of 2-(dimethylphosphinoyl)-2-hydroxy-acetic acid in 30 ml of water. The temperature thereby rises from 23° C. to 38° C. The mixture is stirred at 25° C. for one hour and concentrated on a rotary evaporator and the residue is dehydrated for distillation several times with toluene. After removal of the toluene under a high vacuum, a syrup of nD22 =1.4869 initially forms, and solidifies as a wax after prolonged standing.

Workup

  1. customthereby rises from 23° C. to 38° C
  2. concentrationconcentrated on a rotary evaporator
  3. distillationthe residue is dehydrated for distillation several times with toluene
  4. customAfter removal of the toluene under a high vacuum

Sources & evidence

ORD record
ord-67caa13145dd4bfba03717a1667c82f9
Source dataset
uspto-grants-1986_06
Patent number
US04594098

Reaction notes

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