Ammonia → HCID 13309451, compound

HRID 1981839Notes

Reaction equation

HRID 1981839 reaction equation
[CH3:1][P:2]([CH3:10])([CH:4]([OH:9])[C:5](OC)=[O:6])=[O:3].[NH3:11]>CO>[CH3:1][P:2]([CH3:10])([CH:4]([OH:9])[C:5]([NH2:11])=[O:6])=[O:3]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 13309444HCID 13309444, compound

Product 1

HCID 13309451HCID 13309451, compoundYield 82.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

16.6 g (0.1 mol) of methyl 2-(dimethylphosphinoyl)-2-hydroxyacetate are dissolved in 70 ml of methanol, which has first been gassed with NH3 gas for 10 minutes. After the mixture has been left to stand in a bomb tube at 25° for six days, it is filtered and concentrated and the oily residue is digested with ethyl acetate. 12.4 g (82.2%) of the amide of melting point 155° are obtained.

Workup

  1. waitAfter the mixture has been left
  2. filtrationit is filtered
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-d3f5cdc8507e457f9a06b65359b2e7d4
Source dataset
uspto-grants-1986_06
Patent number
US04594098

Reaction notes

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