Methanesulfonyl chloride → alpha-(1-Benzyl-3-pyrrolidinyl)-alpha,alpha-diphenylacetonitrile

HRID 1981905Notes

Reaction equation

HRID 1981905 reaction equation
[C:1]1([CH2:7][N:8]2[CH2:12][CH2:11][CH:10](O)[CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CS(Cl)(=O)=O.[C:19]1([CH:25]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:26]#[N:27])[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.[Na]>C(N(CC)CC)C>[C:28]1([C:25]([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)([CH:10]2[CH2:11][CH2:12][N:8]([CH2:7][C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[CH2:9]2)[C:26]#[N:27])[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1

Participants

5

Reactant 3

HCID 31297Methanesulfonyl chlorideHCID 69889N-benzyl-3-pyrrolidinolHCID 69737065Sodium diphenylacetonitrile

Product 1

HCID 13633740alpha-(1-Benzyl-3-pyrrolidinyl)-alpha,alpha-diphenylacetonitrile

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The title compound was prepared from 1-(phenylmethyl)-3-pyrrolidinol, methanesulfonylchloride, triethylamine and sodium diphenylacetonitrile by the procedure of U.S. Pat. No. 3,192,210, b.p. 215-218/0.01 mm.

Sources & evidence

ORD record
ord-e9466fe528b24f418812a2d6136c6112
Source dataset
uspto-grants-1986_06
Patent number
US04594343

Reaction notes

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