Triethylamine → HCID 13632607, compound

HRID 1982079Notes

Reaction equation

HRID 1982079 reaction equation
[C:1](Cl)(=[O:4])[CH2:2][CH3:3].[NH2:6][C:7]1[CH:8]=[C:9]([N:13]2[C:17](=[O:18])[CH2:16][C:15]([CH3:21])([CH2:19][CH3:20])[C:14]2=[O:22])[CH:10]=[CH:11][CH:12]=1.C(N(CC)CC)C>CC(C)=O>[C:1]([NH:6][C:7]1[CH:8]=[C:9]([N:13]2[C:17](=[O:18])[CH2:16][C:15]([CH3:21])([CH2:19][CH3:20])[C:14]2=[O:22])[CH:10]=[CH:11][CH:12]=1)(=[O:4])[CH2:2][CH3:3]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 62324Propionyl chlorideHCID 131892171-(3-Aminophenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione

Product 1

HCID 13632607HCID 13632607, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Two and eight-tenths g. of propionylchloride was added dropwise to a well-stirred solution of 7 g. of N-m-aminophenyl-2-methyl-2-ethylsuccinimide and 3.5 g. of triethylamine in 50 ml. of acetone in a water bath. When the reaction was complete (after approximately 30 minutes), the mixture was poured into approximately 500 ml. of water and the product extracted with approximately 50 ml. of methylene chloride, dried and the solvent stripped under vacuum. The yield was 7.7 g. of a thick oil having a nD30 of 1.5510. The product was identified as the title compound by analysis of infrared spectra.

Workup

  1. custom(after approximately 30 minutes)
  2. additionthe mixture was poured into approximately 500 ml
  3. extractionof water and the product extracted with approximately 50 ml
  4. dry with materialof methylene chloride, dried

Sources & evidence

ORD record
ord-bfe0fe673aac482f8079d6119185a769
Source dataset
uspto-grants-1986_06
Patent number
US04595408

Reaction notes

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