Batelapine → 2-methyl-5-(4-methyl-4-oxido-1-piperazinyl)-11H-1,2,4-triazolo[2,3-c][1,3]benzodiazepine

HRID 1982141Notes

Reaction equation

HRID 1982141 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]2[CH2:10][C:9]3[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=3[N:7]=[C:6]([N:15]3[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]3)[N:5]2[N:22]=1.ClC1C=CC=C(C(OO)=[O:31])C=1>C(Cl)Cl>[CH3:1][C:2]1[N:3]=[C:4]2[CH2:10][C:9]3[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=3[N:7]=[C:6]([N:15]3[CH2:16][CH2:17][N+:18]([CH3:21])([O-:31])[CH2:19][CH2:20]3)[N:5]2[N:22]=1

Participants

4

Reactant 2

HCID 60717BatelapineHCID 70297m-Chloroperbenzoic acid

Product 1

HCID 104256602-methyl-5-(4-methyl-4-oxido-1-piperazinyl)-11H-1,2,4-triazolo[2,3-c][1,3]benzodiazepine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 5 g of 2-methyl-5-(4-methyl-1-piperazinyl)-11H-1,2,4-triazolo[2,3-c][1,3]benzodiazepine in 50 ml of methylene chloride is added in portions 3.75 g of m-chloroperbenzoic acid with stirring at 0°. The mixture is then stirred at room temperature overnight and evaporated to dryness. The foamy residue is passed through 100 g of Amberlite IRA-400 ion exchange resin using water as eluent. Evaporation of the eluent gives 2-methyl-5-(4-methyl-4-oxido-1-piperazinyl)-11H-1,2,4-triazolo[2,3-c][1,3]benzodiazepine.

Workup

  1. stirringThe mixture is then stirred at room temperature overnight
  2. customevaporated to dryness
  3. customEvaporation of the eluent

Sources & evidence

ORD record
ord-fc7ef5a2c8e9451ebfaf6f88ab10e1e7
Source dataset
uspto-grants-1986_06
Patent number
US04595535

Reaction notes

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