5-Methyl-3-(o-isothiocyanatobenzyl)-1,2,4-triazole → HCID 23317323, compound

HRID 1982143Notes

Reaction equation

HRID 1982143 reaction equation
[CH3:1][C:2]1[NH:6][N:5]=[C:4]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[N:14]=[C:15]=[S:16])[N:3]=1>C1(C)C=CC=CC=1>[CH3:1][C:2]1[N:3]=[C:4]2[CH2:7][C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[NH:14][C:15](=[S:16])[N:5]2[N:6]=1

Participants

3

Reactant 1

HCID 233173365-Methyl-3-(o-isothiocyanatobenzyl)-1,2,4-triazole

Product 1

HCID 23317323HCID 23317323, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A suspension of 8 g of 5-methyl-3-(o-isothiocyanatobenzyl)-1,2,4-triazole in 100 ml of toluene is refluxed overnight and cooled to room temperature to give 2-methyl-11H-1,2,4-triazolo[2,3-c][1,3]-benzodiazepine-5(6H)-thione. Treatment with methyl iodide as described above yields 2-methyl-5-methylthio-11H-1,2,4-triazolo[2,3-c][1,3]benzodiazepine.

Workup

  1. temperatureis refluxed overnight

Sources & evidence

ORD record
ord-d379b32ace21402c9fc99255a5407147
Source dataset
uspto-grants-1986_06
Patent number
US04595535

Reaction notes

Loading…