反应详情

A suspension of 8 g of 5-methyl-3-(o-isothiocyanatobenzyl)-1,2,4-triazole in 100 ml of toluene is refluxed overnight and cooled to room temperature to give 2-methyl-11H-1,2,4-triazolo[2,3-c][1,3]-benzodiazepine-5(6H)-thione. Treatment with methyl iodide as described above yields 2-methyl-5-methylthio-11H-1,2,4-triazolo[2,3-c][1,3]benzodiazepine.

1. temperatureis refluxed overnight