Triethylamine → HCID 13686103, compound

To a solution of 11.1 g (67mm) of 2-phenyl-2-oxazolin-4-yl methyl alcohol in 150 ml methylene chloride was added 5.25 ml (67 mm) of mesylchloride at 0° C. To this stirred solution under argon was added 9.4 ml (67 mm) of triethylamine over a 30 minute period. The methylene chloride was removed in vacuo. The residue was diluted with 10 ml DMF and pumped on at high vacuum. 8.5 ml (67 mm) of 4-mercaptophenol in 5 ml of DMF was added followed by 9.4 ml (67 mm) of triethyamine. After stirring for 1 day, 0.5 g sodium borohydride was added. After a total of 3 days another 0.5 of sodium borohydride was added followed by a one hour delay. The reaction mixture was poured into 300 ml ethylacetate and washed with 3×150 ml of water, 150 ml 0.1 N, HCl, and brine, then dried over Na2SO4 and concentrated to a yellow oil. Dilution with 50 ml ethyl acetate and seeding gave 4.23 g of a white crystalline solid isolated by filtration mp. 114.5°-165.5° C.

1. customThe methylene chloride was removed in vacuo
2. additionThe residue was diluted with 10 ml DMF
3. addition8.5 ml (67 mm) of 4-mercaptophenol in 5 ml of DMF was added
4. addition0.5 g sodium borohydride was added
5. additionAfter a total of 3 days another 0.5 of sodium borohydride was added
6. waitfollowed by a one hour
7. additionThe reaction mixture was poured into 300 ml ethylacetate
8. washwashed with 3×150 ml of water, 150 ml 0.1 N, HCl, and brine
9. dry with materialdried over Na2SO4
10. concentrationconcentrated to a yellow oil

ORD record

ord-f14e515c55a14be28fc6ff8fc77e4091

Source dataset

uspto-grants-1986_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04595687