Methyl iodide → HCID 23317446, compound

HRID 1982176Notes

Reaction equation

HRID 1982176 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[C:14](=[O:15])[CH2:13][C:12]2[CH:16]=[CH:17][CH:18]=[CH:19][C:11]=2[S:10]1.CI.[C:22](=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH3:22][CH:13]1[C:12]2[CH:16]=[CH:17][CH:18]=[CH:19][C:11]=2[S:10][N:9]([C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=2[O:2][CH3:1])[C:14]1=[O:15]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 23317447HCID 23317447, compound

Product 1

HCID 23317446HCID 23317446, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

5.42 g (20 mmol) of 2,3-dihydro-2-(2-methoxyphenyl)benzothiazin-3-one are dissolved in 100 ml of acetone, and 6.9 ml of methyl iodide and 6.5 g of potassium carbonate are added, and the mixture is heated to reflux for 45 hours. After filtration, the filtrate is concentrated. The product crystallizes on trituration with isopropyl ether.

Workup

  1. temperaturethe mixture is heated
  2. temperatureto reflux for 45 hours
  3. filtrationAfter filtration
  4. concentrationthe filtrate is concentrated
  5. customThe product crystallizes on trituration with isopropyl ether

Sources & evidence

ORD record
ord-0212a62fd09640ccb7bceedb77b7ebc2
Source dataset
uspto-grants-1986_06
Patent number
US04595685

Reaction notes

Loading…