反应详情

A solution of 27 g (0.096 mol) of methyl 4-(2,2-dimethyl-1,3-dioxolan-4-yl)methoxyphenylacetate (3) in 200 ml of tetrahydrofuran (THF) was added slowly to a stirred suspension of 4.0 g of LAH in 300 ml of THF. The mixture was stirred 2 h at room temperature and then treated sequentially with 4 ml of water, 4 ml of 15% NaOH solution, and 12 ml of water. The mixture was filtered and the filtrate evaporated to a residue which was triturated with hexane to afford 24 g of 4-(2,2-dimethyl-1,3-dioxolan-4-yl)methoxyphenylethan-2-ol (4) as a tan solid.

1. filtrationThe mixture was filtered
2. customthe filtrate evaporated to a residue which
3. customwas triturated with hexane